|
KMID : 0848120180430030147
|
|
International Journal of Oral Biology
2018 Volume.43 No. 3 p.147 ~ p.153
|
|
|
Participation of Opioid Pathway in the Central Antinociceptive Effects of Eugenol
|
|
Kang Song-Hee
Kang Sa-Won
Kim Jae-Ho
Kim Hee-Young
Ryu Hyeon-Seo
Bae So-Yeon
Oh Ju-Ae
Lee Jun-Hyuk
Hyun Ji-Hee
Ahn Dong-Kuk
|
|
|
Abstract
|
|
|
|
The aim of the present study was to evaluate the central antinociceptive effects of eugenol after intraperitoneal administration. Experiments were carried out using male Sprague-Dawley rats. Subcutaneous injection of 5% formalin-induced nociceptive behavioral responses was used as the pain model. Subcutaneous injection of 5% formalin significantly produced nociceptive responses by increasing the licking time during nociceptive behavior. Subsequent intraperitoneal injection of 100 mg/kg of eugenol led to a significant decrease in the licking time. However, low dose of eugenol (50 mg/kg) did not affect the nociceptive behavioral responses produced by subcutaneous injection of formalin. Intrathecal injection of 30 μg of naloxone, an opioid receptor antagonist, significantly blocked antinociceptive effects produced by intraperitoneal injection of eugenol. Neither intrathecal injection of methysergide (30 μg), a serotonin receptor antagonist nor phentolamine (30 μg), an α-adrenergic receptor antagonist influenced antinociceptive effects of eugenol, as compared to the vehicle treatment. These results suggest that central opioid pathway participates in mediating the antinociceptive effects of eugenol.
|
|
|
KEYWORD
|
|
|
eugenol, antinociception, formalin, pain, opioid
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|